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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621542
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Rad50
Name: RAD50 double strand break repair protein
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7338996480464CTDNicotine results in increased expression of RAD50 mRNA

PMID:16949557
multiple interactionsISOCRRD:7339006480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD50 mRNA

Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA]

PMID:20230807
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.