GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationISOCRRD:7328616480464CTDGenistein results in increased phosphorylation of CHEK2 protein

PMID:19038232
multiple interactionsISOCRRD:7328616480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]

Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]

U 0126 inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]

PMID:19038232
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.