GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:28544
Term: digitoxin
Definition: A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.
Chemical ID: MESH:D004074
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISOCRRD:7328616480464CTDDigitoxin analog results in decreased expression of CHEK2 protein

Digitoxin results in decreased expression of CHEK2 protein

PMID:22037315
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.