GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621543
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Chek2
Name: checkpoint kinase 2
Acc ID: CHEBI:75249
Term: potassium chromate
Definition: A potassium salt consisting of potassium and chromate ions in a 2:1 ratio.
Chemical ID: MESH:C027373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7328616480464CTDpotassium chromate(VI) results in increased expression of CHEK2 protein modified form

PMID:25977998
increases phosphorylationISOCRRD:7328616480464CTDpotassium chromate(VI) results in increased phosphorylation of CHEK2 protein

PMID:25977998
multiple interactionsISOCRRD:7328616480464CTD2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]

Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form]

Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]

ATM protein promotes the reaction [potassium chromate(VI) results in increased phosphorylation of CHEK2 protein]

Buthionine Sulfoximine promotes the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form]

CHEK2 protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]

PMID:25977998
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.