GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621649
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Plec
Name: plectin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of PLEC mRNA

Tetrachlorodibenzodioxin results in decreased expression of PLEC protein

PMID:16548065, PMID:21215274
affects expressionISOCRRD:7359056480464CTDTetrachlorodibenzodioxin affects the expression of PLEC mRNA

PMID:21570461
increases expressionISOCRRD:7316906480464CTDTetrachlorodibenzodioxin results in increased expression of PLEC mRNA

PMID:22903824
increases expressionISOCRRD:7359056480464CTDTetrachlorodibenzodioxin results in increased expression of PLEC mRNA

PMID:17035482
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.