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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 621870
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13491886480464CTDTetrachlorodibenzodioxin affects the expression of UGCG mRNA

PMID:22298810
affects expressionISORGD:15527456480464CTDTetrachlorodibenzodioxin affects the expression of UGCG mRNA

PMID:21570461
decreases expressionISORGD:13491886480464CTDTetrachlorodibenzodioxin results in decreased expression of UGCG mRNA

PMID:17101203
decreases expressionISORGD:15527456480464CTDTetrachlorodibenzodioxin results in decreased expression of UGCG mRNA

PMID:28213091
increases expressionISORGD:13491886480464CTDTetrachlorodibenzodioxin results in increased expression of UGCG mRNA

PMID:19619570, PMID:19692669, PMID:20106945, PMID:23152189, PMID:26159488
increases expressionISORGD:15527456480464CTDTetrachlorodibenzodioxin results in increased expression of UGCG mRNA

PMID:17942748
multiple interactionsISORGD:13491886480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of UGCG mRNA

PMID:19619570
multiple interactionsISORGD:15527456480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UGCG mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of UGCG mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to UGCG gene]

PMID:17942748, PMID:25975270, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.