GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628596
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tubb5
Name: tubulin, beta 5 class I
Acc ID: CHEBI:35828
Term: arsenic(3+)
Definition: A monoatomic arsenic that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects methylationISOCRRD:16064286480464CTDArsenic affects the methylation of TUBB gene

PMID:25304211
decreases expressionISOCRRD:16064286480464CTDArsenic results in decreased expression of TUBB5 protein

PMID:19818359
multiple interactionsISOCRRD:16064286480464CTD[Arsenic binds to TUBB protein] inhibits the reaction [TUBB protein binds to TUBB protein]

Arsenic binds to and results in decreased activity of TUBB protein

PMID:17499915
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.