GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 628831
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDTretinoin results in increased expression of NR1H4 mRNA

PMID:21274875
multiple interactionsEXP 6480464CTDUrsodeoxycholic Acid inhibits the reaction [Tretinoin results in increased expression of NR1H4 mRNA]

PMID:21274875
increases activityISOCRRD:7341036480464CTDTretinoin results in increased activity of NR1H4 protein

PMID:17567710
multiple interactionsISOCRRD:7341036480464CTDTretinoin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]

Tretinoin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

PMID:25257666
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.