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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 631434
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[SERPINF1 protein co-treated with sodium arsenite] results in increased expression of BBC3 mRNA

PMID:30408888
increases expressionISOCRRD:15524846480464CTDsodium arsenite results in increased expression of BBC3 mRNA

PMID:16166651, PMID:20477944, PMID:30357543
increases response to substanceISOCRRD:15524846480464CTDBBC3 results in increased susceptibility to sodium arsenite

PMID:16166651
multiple interactionsISOCRRD:15524846480464CTDsodium arsenite results in increased expression of and affects the localization of BBC3 protein

sodium arsenite results in increased expression of and results in increased activity of BBC3 protein

TRP53 gene mutant form affects the reaction [sodium arsenite results in increased expression of BBC3 mRNA]

TRP53 gene mutant form affects the reaction [sodium arsenite results in increased expression of BBC3 protein]

TRP73 protein affects the reaction [sodium arsenite results in increased activity of BBC3 protein]

TRP73 protein affects the reaction [sodium arsenite results in increased expression of BBC3 mRNA]

PMID:16166651, PMID:20477944
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.