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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68370
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
Acc ID: CHEBI:71941
Term: tolmetin
Definition: A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
Chemical ID: MESH:D014046
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDTolmetin results in decreased activity of TDO2 protein

PMID:16952380
multiple interactionsEXP 6480464CTD[Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine, [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin, [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin

PMID:16952380
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.