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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68393
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Kcnd2
Name: potassium voltage-gated channel subfamily D member 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDPhenylephrine results in decreased expression of KCND2 mRNA, Phenylephrine results in decreased expression of KCND2 protein

PMID:16385079, PMID:17060317
decreases response to substanceEXP 6480464CTDKCND2 protein results in decreased susceptibility to Phenylephrine

PMID:12403671
multiple interactionsEXP 6480464CTDCABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA], CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein], KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein], KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:12403671, PMID:17060317
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.