Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68945
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDperfluorooctanoic acid results in increased activity of CYP4A1 protein

PMID:8011682
increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of CYP4A1 mRNA, perfluorooctanoic acid results in increased expression of CYP4A1 protein

PMID:19162173, PMID:19407336, PMID:20614104, PMID:21723365, PMID:28511854, PMID:8134918
affects expressionISORGD:16233166480464CTDperfluorooctanoic acid affects the expression of CYP4A22 mRNA

PMID:19429403
increases expressionISORGD:16038646480464CTDperfluorooctanoic acid results in increased expression of CYP4A1 mRNA, perfluorooctanoic acid results in increased expression of CYP4A22 mRNA

PMID:21723365, PMID:27153767
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.