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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68945
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDClofibrate affects the expression of CYP4A1 mRNA

PMID:18246545
increases expressionEXP 6480464CTDClofibrate results in increased expression of CYP4A1 mRNA, Clofibrate results in increased expression of CYP4A1 protein, Clofibrate results in increased expression of CYP4A22 mRNA

PMID:10476907, PMID:11328961, PMID:12851107, PMID:12883083, PMID:14965361, PMID:15033592, PMID:15093671, PMID:15585944, PMID:17126302, PMID:18246545, PMID:19224547, PMID:19647067, PMID:19850644, PMID:22008536, PMID:27665778, PMID:2766933, PMID:28495587, PMID:3027069, PMID:7701848
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Clofibrate] results in increased expression of CYP4A1 protein, Clofibrate inhibits the reaction [H2AZ1 protein binds to CYP4A1 gene]

PMID:10550479, PMID:28495587
increases expressionISORGD:16233166480464CTDClofibrate results in increased expression of CYP4A12B mRNA

PMID:17585979
multiple interactionsISORGD:16233166480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of CYP4A12B mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP4A12B mRNA]

PMID:17585979
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.