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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 68945
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp4a1
Name: cytochrome P450, family 4, subfamily a, polypeptide 1
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDCYP4A1 protein affects the susceptibility to Phenylephrine

PMID:11124159
increases response to substanceEXP 6480464CTDCYP4A1 protein results in increased susceptibility to Phenylephrine

PMID:12388396
multiple interactionsEXP 6480464CTD20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid affects the reaction [CYP4A1 protein affects the susceptibility to Phenylephrine], 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid inhibits the reaction [DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]], 20-hydroxyeicosa-6(Z), 15(Z)-dienoic acid inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine], DDMS inhibits the reaction [CYP4A1 protein results in increased susceptibility to Phenylephrine]

PMID:11124159, PMID:12388396
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.