CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16130
Term: DDT
Definition: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.
Chemical ID: MESH:D003634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDDDT results in increased activity of NR1I2 protein

PMID:15548381, PMID:25680588
multiple interactionsISOCRRD:691056480464CTD[DDT co-treated with Dieldrin] results in increased activity of NR1I2 protein

DDT binds to and results in increased activity of NR1I2 protein

PMID:16054614, PMID:20686338, PMID:25028461
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.