GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of NR1I2 mRNA

Lithocholic Acid results in decreased expression of NR1I2 protein

PMID:20888898, PMID:21311750
multiple interactionsEXP 6480464CTD[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA

[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23/3A1 mRNA

[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]

Lithocholic Acid binds to and results in increased activity of NR1I2 protein

PMID:12370413, PMID:21311750
decreases response to substanceISOCRRD:691056480464CTDNR1I2 protein results in decreased susceptibility to Lithocholic Acid

PMID:12370413
decreases response to substanceISOCRRD:691066480464CTDNR1I2 protein results in decreased susceptibility to Lithocholic Acid

PMID:15358766
increases activityISOCRRD:691056480464CTDLithocholic Acid results in increased activity of NR1I2 protein

PMID:22561792, PMID:27871908
increases localizationISOCRRD:691056480464CTDLithocholic Acid results in increased localization of NR1I2 protein

PMID:21977915
increases response to substanceISOCRRD:691066480464CTDNR1I2 results in increased susceptibility to Lithocholic Acid

PMID:19797606
multiple interactionsISOCRRD:691056480464CTD[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA

[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA

[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA

[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA

Lithocholic Acid analog binds to and results in increased activity of NR1I2 protein

Lithocholic Acid binds to and results in increased activity of NR1I2 protein

NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA]

PMID:14570758, PMID:15883047, PMID:16054614, PMID:17696253, PMID:17963371, PMID:22561792
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.