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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:27666
Term: actinomycin D
Definition: An actinomycin that has formula C62H86N12O16.
Chemical ID: MESH:D003609
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [Clofibrate results in increased expression of NR1I2 protein], Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA], Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]

PMID:15826607, PMID:20599767
multiple interactionsISORGD:691056480464CTDDactinomycin inhibits the reaction [ochratoxin A results in decreased expression of NR1I2 mRNA]

PMID:26341324
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.