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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDCisplatin results in increased activity of NR1I2 protein

PMID:15650019
multiple interactionsISOCRRD:691056480464CTDCisplatin promotes the reaction [NR1I2 protein binds to MED1 protein]

Cisplatin promotes the reaction [NR1I2 protein binds to NCOA3 protein]

PMID:15650019
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