GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:28088
Term: genistein
Definition: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDGenistein results in increased activity of NR1I2 protein

PMID:28728110
increases expressionISOCRRD:691056480464CTDGenistein results in increased expression of NR1I2 mRNA

PMID:29933105
multiple interactionsISOCRRD:691056480464CTDGenistein binds to and results in increased activity of NR1I2 protein

Genistein results in increased activity of and results in increased expression of NR1I2 protein

sulforafan inhibits the reaction [Genistein results in increased activity of NR1I2 protein]

PMID:16054614, PMID:29933105
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.