GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISOCRRD:691056480464CTDperfluorooctane sulfonic acid results in increased activity of NR1I2 protein

PMID:28115241
increases expressionISOCRRD:691066480464CTDperfluorooctane sulfonic acid results in increased expression of NR1I2 mRNA

PMID:21705711
multiple interactionsISOCRRD:691056480464CTD[perfluorooctane sulfonic acid co-treated with perfluorononanoic acid] results in increased activity of NR1I2 protein

[perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid] results in increased activity of NR1I2 protein

PMID:28115241
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.