GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69057
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDFlutamide results in decreased expression of NR1I2 mRNA

PMID:24793618
increases activityISOCRRD:691056480464CTDFlutamide results in increased activity of NR1I2 protein

PMID:20041327, PMID:28728110
multiple interactionsISOCRRD:691056480464CTD[Flutamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA

Flutamide binds to and results in increased activity of NR1I2 protein

NR1I2 protein promotes the reaction [Flutamide results in increased expression of and results in increased activity of ABCB1 protein]

PMID:18839173, PMID:20041327
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.