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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69073
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mdk
Name: midkine
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of MDK mRNA]

PMID:12660332
increases expressionISOCRRD:691426480464CTDTretinoin results in increased expression of MDK mRNA

PMID:17138961, PMID:23724009, PMID:23830798
increases expressionISOCRRD:691436480464CTDTretinoin results in increased expression of MDK mRNA

PMID:16604517
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.