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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69073
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mdk
Name: midkine
Acc ID: CHEBI:51062
Term: (RS)-amphetamine
Definition: null
Definition Source(s): ChemIDplus:300-62-9, DrugBank:DB00182
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISOCRRD:691436480464CTDMDK gene mutant form results in decreased susceptibility to Amphetamine

PMID:23459167
multiple interactionsISOCRRD:691436480464CTD[MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of and results in increased phosphorylation of ERP29 protein

[MDK gene mutant form results in decreased susceptibility to Amphetamine] which results in increased expression of CCT2 protein

Amphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ATP5D protein]

Amphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of ENO2 protein]

Amphetamine inhibits the reaction [MDK gene mutant form results in decreased expression of FAH protein]

Amphetamine promotes the reaction [MDK gene mutant form results in decreased expression of ATP5A1 protein]

Amphetamine promotes the reaction [MDK gene mutant form results in increased expression of ALAD protein]

MDK gene mutant form inhibits the reaction [Amphetamine results in increased expression of RAN protein]

MDK gene mutant form promotes the reaction [Amphetamine results in decreased expression of ALDH1A1 protein]

PMID:23459167
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