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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein], Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein], Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:10640773, PMID:14660655, PMID:26514923
multiple interactionsISORGD:105116480464CTDAcetylcysteine inhibits the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of EGFR protein], Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased activity of EGFR protein], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of EGFR mRNA], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein], Acetylcysteine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of and results in increased activity of EGFR protein], Acetylcysteine inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:15520183, PMID:17942915, PMID:21220312, PMID:23948867, PMID:28123000
multiple interactionsISORGD:25436480464CTDAcetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein], Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of EGFR protein], Acetylcysteine inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:15849355, PMID:16261333, PMID:26368632
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.