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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of EGFR mRNA

PMID:20678512
increases expressionEXP 6480464CTDbisphenol A results in increased expression of EGFR mRNA, bisphenol A results in increased expression of EGFR protein

PMID:29275510, PMID:30022450, PMID:31016847
increases phosphorylationEXP 6480464CTDbisphenol A results in increased phosphorylation of EGFR protein

PMID:28426875, PMID:29383186, PMID:31075703
multiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein], bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]], bicalutamide inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein], bisphenol A promotes the reaction [EGFR protein binds to AR protein], bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein], Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]], Fulvestrant inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein], Gefitinib inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to AR protein]], Gefitinib inhibits the reaction [bisphenol A promotes the reaction [EGFR protein binds to ESR2 protein]], Gefitinib inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein], GW 583340 inhibits the reaction [bisphenol A results in increased phosphorylation of EGFR protein]

PMID:28426875, PMID:29383186, PMID:31075703
decreases expressionISORGD:105116480464CTDbisphenol A results in decreased expression of EGFR mRNA

PMID:26063408
increases expressionISORGD:105116480464CTDbisphenol A results in increased expression of EGFR mRNA

PMID:30951980
increases expressionISORGD:25436480464CTDbisphenol A results in increased expression of EGFR mRNA

PMID:25181051
increases methylationISORGD:25436480464CTDbisphenol A results in increased methylation of EGFR gene

PMID:28505145
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.