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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases phosphorylationEXP 6480464CTDZinc Sulfate results in increased phosphorylation of EGFR protein

PMID:10564177, PMID:11943669
multiple interactionsEXP 6480464CTD4-((3-bromophenyl)amino)-6, 7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased phosphorylation of EGFR protein], Zinc Sulfate results in increased phosphorylation of and results in increased activity of EGFR protein

PMID:16410015
increases phosphorylationISORGD:25436480464CTDZinc Sulfate results in increased phosphorylation of EGFR protein

PMID:19946718
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.