Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDClofibrate results in decreased expression of EGFR protein

PMID:21080969
multiple interactionsEXP 6480464CTDClofibrate inhibits the reaction [CREBBP protein binds to EGFR promoter], Clofibrate inhibits the reaction [NCOA1 protein binds to EGFR promoter], CREBBP protein inhibits the reaction [Clofibrate results in decreased expression of EGFR protein], NCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of EGFR protein]

PMID:21080969
decreases expressionISORGD:105116480464CTDClofibrate results in decreased expression of EGFR mRNA

PMID:17585979
decreases expressionISORGD:25436480464CTDClofibrate results in decreased expression of EGFR protein

PMID:2404574
multiple interactionsISORGD:105116480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of EGFR mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of EGFR mRNA]

PMID:17585979
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.