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GENE - TERM ANNOTATION REPORT

CRRD ID: 69152
Species: Homo sapiens
CRRD Object: Gene
Symbol: EGFR
Name: epidermal growth factor receptor
Acc ID: DOID:9006169
Term: Head and Neck Neoplasms
Definition: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Definition Source(s): MESH:D006258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 EXP 11554173CTDCTD Direct Evidence: marker/mechanism

PMID:12942316, PMID:15342401, PMID:23917044
 IAGPRGD:128380158554872ClinVarClinVar Annotator: match by term: Head and Neck Neoplasms

PMID:21274259
 IAGPRGD:128436268554872ClinVarClinVar Annotator: match by term: Head and Neck Neoplasms

PMID:18089823, PMID:24934779, PMID:25157968
 IAGPRGD:128476668554872ClinVarClinVar Annotator: match by term: Head and Neck Neoplasms

PMID:23578570
 IMP 5131641CRRD  
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.