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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69274
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Casp2
Name: caspase 2
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:16048506480464CTD[Boc-D-FMK co-treated with Sirolimus] results in increased cleavage of CASP2 protein

Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP2 protein]

PMID:15767555
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