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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69313
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:34714
Term: dimethoate
Definition: A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Chemical ID: MESH:D004117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityEXP 6480464CTDDimethoate affects the activity of ACHE protein

PMID:25082528
decreases activityEXP 6480464CTDDimethoate results in decreased activity of ACHE protein

PMID:15033006, PMID:16112789, PMID:17997881, PMID:26769589, PMID:3247000
decreases expressionEXP 6480464CTDDimethoate results in decreased expression of ACHE protein

PMID:25967365
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]

PMID:26769589
decreases activityISOCRRD:7358786480464CTDDimethoate results in decreased activity of ACHE protein

PMID:16112538, PMID:16701032, PMID:18070496, PMID:19793545, PMID:19917271
decreases activityISOCRRD:7358796480464CTDDimethoate results in decreased activity of ACHE protein

PMID:16833148, PMID:26482405
multiple interactionsISOCRRD:7358786480464CTDpralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]

PMID:16112538, PMID:19917271
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.