Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69313
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDCadmium Chloride results in decreased activity of ACHE protein

PMID:15304303
decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of ACHE mRNA

Cadmium Chloride results in decreased expression of ACHE protein

PMID:27389774
increases activityEXP 6480464CTDCadmium Chloride results in increased activity of ACHE protein

PMID:25064450
increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of ACHE mRNA

PMID:25201352
increases response to substanceEXP 6480464CTDACHE mRNA results in increased susceptibility to Cadmium Chloride

PMID:27377441
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Cadmium Chloride results in decreased expression of ACHE mRNA]

Quercetin inhibits the reaction [Cadmium Chloride results in decreased expression of ACHE protein]

Quercetin inhibits the reaction [Cadmium Chloride results in increased activity of ACHE protein]

PMID:25064450, PMID:27389774
affects expressionISOCRRD:7358796480464CTDCadmium Chloride affects the expression of ACHE mRNA alternative form

PMID:27377441
decreases expressionISOCRRD:7358796480464CTDCadmium Chloride results in decreased expression of ACHE mRNA alternative form

PMID:26026611
increases activityISOCRRD:7358796480464CTDCadmium Chloride results in increased activity of ACHE protein

PMID:22101474
increases expressionISOCRRD:7358796480464CTDCadmium Chloride results in increased expression of ACHE mRNA

PMID:26026611
increases response to substanceISOCRRD:7358796480464CTDACHE mRNA results in increased susceptibility to Cadmium Chloride

PMID:27377441
multiple interactionsISOCRRD:7358796480464CTD[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in decreased expression of CHAT protein

[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of APP protein modified form

[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of GSK3B mRNA

[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein

[[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of MAPT protein modified form

[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form

ACHE mRNA promotes the reaction [Cadmium Chloride results in decreased expression of CHAT protein]

ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of APP protein modified form]

ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of GSK3B mRNA]

ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of MAPT protein modified form]

ACHE mRNA promotes the reaction [Cadmium Chloride results in increased expression of MAPT protein]

ACHE mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]

ACHE mutant form inhibits the reaction [Cadmium Chloride results in increased activity of CASP7 protein]

Cadmium Chloride affects the activity of and results in decreased expression of ACHE protein

PMID:25201352, PMID:26026611, PMID:27377441
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.