GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 69316
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Irs2
Name: insulin receptor substrate 2
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDChlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein

Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein

PMID:17512020, PMID:18308779
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.