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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 708428
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7332906480464CTDpirinixic acid results in increased expression of AKR1C18 mRNA

PMID:17950772, PMID:18301758, PMID:20032461, PMID:20813756, PMID:23811191
multiple interactionsISOCRRD:7332906480464CTDPPARA protein promotes the reaction [pirinixic acid results in increased expression of AKR1C18 mRNA]

PMID:17950772, PMID:20032461
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.