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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 708428
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:37454
Term: 9,10-phenanthroquinone
Definition: A phenanthrene that has formula C14H8O2.
Chemical ID: MESH:C005399
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13528886480464CTD9, 10-phenanthrenequinone results in increased expression of AKR1C3 protein

PMID:29108775
increases metabolic processingISORGD:13528886480464CTDAKR1C3 protein results in increased metabolism of 9, 10-phenanthrenequinone

PMID:17950253, PMID:29108775
increases reductionISORGD:13528886480464CTDAKR1C3 protein results in increased reduction of 9, 10-phenanthrenequinone

PMID:19442656, PMID:21851338, PMID:23261716
multiple interactionsISORGD:13528886480464CTD[AKR1C3 protein results in increased reduction of 9, 10-phenanthrenequinone] which results in increased abundance of Superoxides, AKR1C3 protein results in increased reduction of and affects the activity of 9, 10-phenanthrenequinone, Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9, 10-phenanthrenequinone], Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9, 10-phenanthrenequinone], N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9, 10-phenanthrenequinone]

PMID:17950253, PMID:19442656, PMID:21910479
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.