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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 70981
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Bco1
Name: beta-carotene oxygenase 1
Acc ID: CHEBI:17579
Term: beta-carotene
Definition: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.
Chemical ID: MESH:D019207
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases oxidationEXP 6480464CTDBCO1 protein results in increased oxidation of beta Carotene

PMID:9526112
multiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]], Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene], Vitamin E inhibits the reaction [Oxidants inhibits the reaction [BCO1 protein results in increased oxidation of beta Carotene]]

PMID:9526112
affects response to substanceISORGD:13323996480464CTDBCO1 protein affects the susceptibility to beta Carotene

PMID:24657404
increases expressionISORGD:13465526480464CTDbeta Carotene results in increased expression of BCO1 mRNA

PMID:16186334
multiple interactionsISORGD:13323996480464CTD[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ACAD9 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of AEBP1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of APPBP2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ARHGAP26 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ATP8B1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CDCA8 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CENPE mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CLCN3 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of COQ7 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of CTNNAL1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DTWD2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EDN1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of EIF2S1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FOXM1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of FZD6 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of IRX4 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ITM2A mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of KIF11 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LANCL1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of LMNB2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL21A mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of METTL9 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MRPL57 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of MTCH2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NCKAP1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of NOM1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PARD6A mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PCDH1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RPP14 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of RRM1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TFCP2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of THOC7 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TMEM209 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TTC21B mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TWF1 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of TYMP mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of YTHDC2 mRNA, [BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of ZDHHC3 mRNA

PMID:24657404
multiple interactionsISORGD:13465526480464CTDbeta Carotene results in increased expression of and results in increased activity of BCO1 protein

PMID:16186334
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.