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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 71039
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Mgll
Name: monoglyceride lipase
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDChlorpyrifos results in decreased activity of MGLL protein

PMID:23761300, PMID:23933531, PMID:25447325, PMID:26215119, PMID:26642910
multiple interactionsEXP 6480464CTD[Chlorpyrifos results in decreased activity of MGLL protein] which results in increased abundance of glyceryl 2-arachidonate

PMID:23761300, PMID:26642910
multiple interactionsISORGD:7370656480464CTDChlorpyrifos inhibits the reaction [Dietary Fats results in increased activity of MGLL protein]

PMID:29935250
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.