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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 727915
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:13466136480464CTDresveratrol results in increased expression of CYP27A1 mRNA

resveratrol results in increased expression of CYP27A1 protein

PMID:23041272
increases expressionISOCRRD:15504756480464CTDresveratrol results in increased expression of CYP27A1 mRNA

PMID:22610192
multiple interactionsISOCRRD:13466136480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 mRNA]

2-chloro-5-nitrobenzanilide inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]

ADORA2A protein promotes the reaction [resveratrol results in increased expression of CYP27A1 protein]

PPARG protein promotes the reaction [resveratrol results in increased expression of CYP27A1 mRNA]

PPARG protein promotes the reaction [resveratrol results in increased expression of CYP27A1 protein]

ZM 241385 inhibits the reaction [resveratrol results in increased expression of CYP27A1 protein]

PMID:23041272
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.