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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCalcitriol results in decreased expression of IL2 mRNA, Calcitriol results in decreased expression of IL2 protein

PMID:2783896, PMID:3093070
decreases secretionEXP 6480464CTDCalcitriol results in decreased secretion of IL2 protein

PMID:3093070
multiple interactionsEXP 6480464CTDCalcitriol inhibits the reaction [IL2 protein results in increased phosphorylation of AKT1 protein], Calcitriol inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein], Calcitriol inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]

PMID:15879110
decreases expressionISORGD:6200476480464CTDCalcitriol results in decreased expression of IL2 protein

PMID:11679963, PMID:3002965
decreases expressionISORGD:7333156480464CTDCalcitriol results in decreased expression of IL2 protein

PMID:2525134
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.