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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA, Cyclosporine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL2 protein], Cyclosporine inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IL2 protein], Cyclosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]

PMID:1371491, PMID:24603311, PMID:29594315
affects expressionISORGD:6200476480464CTDCyclosporine affects the expression of IL2 mRNA, Cyclosporine affects the expression of IL2 protein

PMID:24971338
decreases expressionISORGD:6200476480464CTDCyclosporine results in decreased expression of IL2 mRNA

PMID:10454224
increases expressionISORGD:6200476480464CTDCyclosporine results in increased expression of IL2 protein

PMID:24462674
multiple interactionsISORGD:6200476480464CTDcelecoxib inhibits the reaction [Cyclosporine results in increased expression of IL2 protein]

PMID:24462674
multiple interactionsISORGD:7333156480464CTD[Cyclosporine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein, Cyclosporine inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of IL2 protein], Cyclosporine inhibits the reaction [Zymosan results in increased expression of IL2 protein]

PMID:15588918, PMID:17312158, PMID:7871569
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.