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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7333156480464CTDToluene 2, 4-Diisocyanate results in decreased expression of IL2 mRNA

PMID:11379042
increases expressionISORGD:7333156480464CTDToluene 2, 4-Diisocyanate results in increased expression of IL2 mRNA, Toluene 2, 4-Diisocyanate results in increased expression of IL2 protein

PMID:18652873, PMID:22381623
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.