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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:6200476480464CTDIsoproterenol results in increased expression of IL2 mRNA, Isoproterenol results in increased expression of IL2 protein

PMID:25045214
multiple interactionsISORGD:6200476480464CTDSirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA], Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein], TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 mRNA]], TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in increased expression of IL2 protein]]

PMID:25045214
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.