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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730858
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL2
Name: interleukin 2
Acc ID: CHEBI:71200
Term: tofacitinib
Definition: A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.
Chemical ID: MESH:C479163
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7333156480464CTDtofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of AKT1 protein], tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5A protein], tofacitinib inhibits the reaction [IL2 protein results in increased phosphorylation of STAT5B protein]

PMID:21155605, PMID:21383241
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.