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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases mutagenesisEXP 6480464CTDUrethane results in increased mutagenesis of HRAS gene

PMID:10779650, PMID:12765245
increases response to substanceEXP 6480464CTDHRAS protein results in increased susceptibility to Urethane

PMID:10779650, PMID:11552296
multiple interactionsEXP 6480464CTDHRAS protein promotes the reaction [Urethane results in increased expression of CCND1 protein]

PMID:11307925
increases expressionISORGD:107306480464CTDUrethane results in increased expression of HRAS mRNA

PMID:18465119
increases response to substanceISORGD:107306480464CTDHRAS protein results in increased susceptibility to Urethane

PMID:15902970, PMID:26558449
multiple interactionsISORGD:107306480464CTDHRAS protein promotes the reaction [Urethane results in increased expression of AURKB mRNA], HRAS protein promotes the reaction [Urethane results in increased expression of CCNB1 mRNA], HRAS protein promotes the reaction [Urethane results in increased expression of EREG mRNA], tocopheryloxybutyric acid inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]], troglitazone promotes the reaction [HRAS protein results in increased susceptibility to Urethane], Urethane promotes the reaction [RAF1 protein binds to HRAS protein], Vitamin E inhibits the reaction [Urethane promotes the reaction [RAF1 protein binds to HRAS protein]]

PMID:11062179, PMID:26558449
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.