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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases response to substanceEXP 6480464CTDHRAS protein results in increased susceptibility to 9, 10-Dimethyl-1, 2-benzanthracene

PMID:11376698, PMID:12117780
multiple interactionsEXP 6480464CTD4-octylphenol affects the reaction [HRAS protein results in increased susceptibility to 9, 10-Dimethyl-1, 2-benzanthracene], Estradiol affects the reaction [HRAS protein results in increased susceptibility to 9, 10-Dimethyl-1, 2-benzanthracene]

PMID:12117780
increases mutagenesisISORGD:107306480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene

PMID:1375869, PMID:20103723
multiple interactionsISORGD:107306480464CTD[9, 10-Dimethyl-1, 2-benzanthracene co-treated with Benzoyl Peroxide] results in increased expression of HRAS mRNA, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Benzoyl Peroxide] results in increased mutagenesis of HRAS gene, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate co-treated with mezerein] results in increased expression of HRAS mRNA, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HRAS mRNA, [9, 10-Dimethyl-1, 2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in increased mutagenesis of HRAS gene, [Ellagic Acid co-treated with Plant Extracts] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [Ellagic Acid co-treated with resveratrol] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [Glucaric Acid co-treated with Plant Extracts] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [Glucaric Acid co-treated with resveratrol] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [resveratrol co-treated with Plant Extracts] inhibits the reaction [9, 10-Dimethyl-1, 2-benzanthracene results in increased mutagenesis of HRAS gene], [Tetradecanoylphorbol Acetate co-treated with 9, 10-Dimethyl-1, 2-benzanthracene co-treated with geraniol] affects the localization of HRAS protein, [Tetradecanoylphorbol Acetate co-treated with 9, 10-Dimethyl-1, 2-benzanthracene] results in increased expression of HRAS protein

PMID:11241758, PMID:20103723, PMID:22760862, PMID:3115617
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.