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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA], Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR193A-1 mRNA], Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR21-1 mRNA], Sirolimus inhibits the reaction [HRAS protein mutant form results in increased expression of MIR21-2 mRNA], Sirolimus inhibits the reaction [HRAS protein mutant form results in increased phosphorylation of RPS6 protein]

PMID:30619488
multiple interactionsISORGD:107306480464CTD[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein, [Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein, PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of ERN1 protein], PPARD protein affects the reaction [[Sirolimus co-treated with HRAS protein] results in decreased expression of HSPA5 protein]

PMID:24898257
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.