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CRRD ID: 730881
Species: Homo sapiens
CRRD Object: Gene
Symbol: HRAS
Name: HRas proto-oncogene, GTPase
Acc ID: DOID:3068
Term: glioblastoma multiforme
Definition: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Definition Source(s): MESH:D005909,,,,
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IAGPRGD:85632248554872ClinVarClinVar Annotator: match by term: Glioblastoma

PMID:11150980, PMID:16170316, PMID:16329078, PMID:16372351, PMID:16443854, PMID:16835863, PMID:16881968, PMID:16969868, PMID:17054105, PMID:17412879, PMID:18039947, PMID:18978862, PMID:19206176, PMID:19371735, PMID:19669404, PMID:20660566, PMID:20979192, PMID:21834037, PMID:21850009, PMID:22087699, PMID:22317973, PMID:22683711, PMID:23751039, PMID:24033266, PMID:24129065, PMID:25741868, PMID:26619011, PMID:28492532, PMID:29493581
 IAGPRGD:85632258554872ClinVarClinVar Annotator: match by term: Glioblastoma

PMID:12210337, PMID:14608654, PMID:16155195, PMID:16170316, PMID:17250658, PMID:17979197, PMID:18470943, PMID:21850009, PMID:22317973, PMID:24169525, PMID:24224811, PMID:25741868, PMID:25914166, PMID:26619011, PMID:27195699, PMID:27589201, PMID:28027064, PMID:28390077, PMID:28492532, PMID:29073591
 IAGPRGD:85691268554872ClinVarClinVar Annotator: match by term: Glioblastoma

PMID:16443854, PMID:18039947, PMID:19382114, PMID:21850009, PMID:22499344, PMID:22683711, PMID:22926243, PMID:24033266, PMID:25157968, PMID:25741868, PMID:26619011
severityIEP 13702872CRRD  
 ISORGD:1073013702475CRRDDNA:missense mutation:cds:p.G61L(human)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.