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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pleasant odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDOzone results in decreased expression of IL5 mRNA

PMID:10226068
multiple interactionsEXP 6480464CTD[Vehicle Emissions co-treated with Ozone] results in decreased expression of IL5 protein

PMID:27058360
increases expressionISORGD:107996480464CTDOzone results in increased expression of IL5 protein

PMID:18315731
increases expressionISORGD:29006480464CTDOzone results in increased expression of IL5 protein

PMID:28623178
multiple interactionsISORGD:107996480464CTD[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA, [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL5 protein, IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL5 protein], TNFRSF1B affects the reaction [[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA]

PMID:23434795, PMID:27472835
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.