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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:29006480464CTDbisphenol A results in decreased expression of IL5 mRNA

PMID:25181051
increases expressionISORGD:107996480464CTDbisphenol A results in increased expression of IL5 protein

PMID:29161229, PMID:29737898
multiple interactionsISORGD:107996480464CTD[bisphenol A affects the susceptibility to Ovalbumin] which results in increased expression of IL5 protein, [bisphenol A co-treated with OVAL protein] results in increased expression of IL5 mRNA, [Ovalbumin co-treated with bisphenol A] results in increased expression of and results in increased secretion of IL5 protein

PMID:27087817, PMID:29737898
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.