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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:50095
Term: bucladesine
Definition: A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.
Chemical ID: MESH:D003994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDBucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein], Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein], Bucladesine inhibits the reaction [Miconazole results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [Miconazole results in decreased secretion of IL5 protein], Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein], Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]

PMID:11886533
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.