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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730927
Species: Homo sapiens
CRRD Object: Gene
Symbol: IL5
Name: interleukin 5
Acc ID: CHEBI:9448
Term: terbinafine
Definition: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.
Chemical ID: MESH:C041359
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDterbinafine results in decreased expression of IL5 mRNA

PMID:11886533, PMID:15284827
decreases secretionEXP 6480464CTDterbinafine results in decreased secretion of IL5 protein

PMID:11886533, PMID:15284827
multiple interactionsEXP 6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA], 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein], Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA], Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL5 protein], Colforsin inhibits the reaction [terbinafine results in decreased expression of IL5 mRNA], Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL5 protein]

PMID:11886533
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.